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Major toxicity of 5-FU is exerted onthe bone marrow and g.i.t.
This inhibition of the abilityof TGF-? to induce adaptive Tregs is the result of the cAMP-induced PKA blocking of ERKand JNK activation, which augments TGF-? induction of FOXP3 (Cao 2013). One of the gob-let cells shows mucinogen granules (M) in its apical cytoplasm.
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